Physician's Weekly Podcast

Facing a Crisis Like No Other, The KarMMa-3 Trial

April 19, 2023 Physician's Weekly Season 3 Episode 89
Physician's Weekly Podcast
Facing a Crisis Like No Other, The KarMMa-3 Trial
Show Notes

Steven Woolf, MD, MPH (Virginia Commonwealth University School of Medicine), discusses the ominous implications of the largest increase in US all-cause pediatric mortality rates in at least 50 years (up 20% in 2019-2021). A nation that begins losing its most cherished population—its children—faces a crisis like no other. Also, Sergio Giralt, MD, reviews results from the MarMMa-3 trial, which investigated the safety and efficacy of idecabtagene vicleucel for relapsed or refractory multiple myeloma. The findings were recently published in the New England Journal of Medicine. How will this change the treatment landscape for patients with multiple myeloma?


 Enjoy listening!

 

Additional reading:

Woolf SH, Wolf ER, Rivara FP. The New Crisis of Increasing All-Cause Mortality in US Children and Adolescents. JAMA. 2023 Mar 28;329(12):975-976. 

Rodriguez-Otero P, Ailawadhi S, Arnulf B, Patel K, Cavo M, Nooka AK, Manier S, Callander N, Costa LJ, Vij R, Bahlis NJ, Moreau P, Solomon SR, Delforge M, Berdeja J, Truppel-Hartmann A, Yang Z, Favre-Kontula L, Wu F, Piasecki J, Cook M, Giralt S. Ide-cel or Standard Regimens in Relapsed and Refractory Multiple Myeloma. N Engl J Med. 2023 Mar 16;388(11):1002-1014. 


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