Physician's Weekly Podcast

Adverse Childhood Experiences Up Risk for Later Dementia & Two Novel Athersclerosis Biomarkers in Psoriatic Disease

May 04, 2022 Physician's Weekly
Physician's Weekly Podcast
Adverse Childhood Experiences Up Risk for Later Dementia & Two Novel Athersclerosis Biomarkers in Psoriatic Disease
Show Notes

Welcome to this episode of Physician’s Weekly Podcast. My name is Dr. Rachel Giles, from Medicom Medical Publishers, in collaboration with Physician’s Weekly. This episode has 2 inDEPTH  interviews with top-line specialists who just published studies we think are interesting to our physician colleagues. 

Both interviews were conducted by Physician’s Weekly’s own Senior Editor Martta Kelly. Later in this episode, she interviews  Dr. Lihi Eder, from the Women’s College Research Institute and University of Toronto, in Canada about biomarkers of cardiovascular disease in patients with psoriatic disease, which her research group just published in Arthritis & Rheumatology. The researchers wondered if 2 biomarkers may reflect atherosclerosis burden independent of traditional cardiovascular risk factors in over 1000 patients with psoriatic disease with a mean follow-up of over 7 years. The first clinical CV event was the study’s primary endpoint. Keep listening to find out the results. 

But first, Physician’s Weekly speaks with Dr. Heather Schickedanz. Dr. Schickedanz is a geriatrician affiliated with multiple hospitals, including UCLA Medical Center, in Los Angeles. When researchers first discovered a link in the late 1990s between childhood adversity and chronic health problems later in life, the real revelation was how common those experiences were across all socioeconomic groups.

Adverse childhood experiences (ACEs) are universal, yet highlights some disparities among socioeconomic groups. People with low-income and educational attainment, people of color, and people who identified as gay, lesbian or bisexual had a significantly higher chance of having experienced adversity in childhood.

It is estimated that three out of five adults across the U.S. had at least one adverse experience in their childhood, such as divorce, a parent's death, physical or emotional abuse, or a family member's incarceration or substance abuse problem. A quarter of adults have at least three such experiences in childhood, which – according to other research — increases their risk for most common chronic diseases, from heart disease and cancer to depression and substance abuse. Here we talk to Dr. Schickendanz about her recently published research on the association between Adverse Childhood Experiences and Dementia in American Older Adults.

Enjoy listening!


Colaco K, Lee KA, Akhtari S, Winer R, Welsh P, Sattar N, McInnes IB, Chandran V, Harvey P, Cook RJ, Gladman DD, Piguet V, Eder L. Association of Cardiac Biomarkers with Cardiovascular Outcomes in Patients with Psoriatic Arthritis and Psoriasis: A Longitudinal Cohort Study. Arthritis Rheumatol. 2022 Mar 8. doi: 10.1002/art.42079. Epub ahead of print. PMID: 35261189.


Schickedanz HB, Jennings LA, Schickedanz A. The Association Between Adverse Childhood Experiences and Positive Dementia Screen in American Older Adults. J Gen Intern Med. 2021 Nov 15. doi: 10.1007/s11606-021-07192-8. Epub ahead of print. PMID: 34782990.

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